I sign up for a lot of new services. The homepages I find convincing usually:
- Supply a hook. Uniqueness is great, obviously, but specificity can work just as well. Show concrete numbers or examples to back up claims.
- Provide a clear and compelling path to the call to action. Display information in a logical order that helps, not hinders, the decision-making process.
- Tell a story of happily ever after. Describe the user as having a problem or goal and present the product as a solution.
The homepages that confuse me the most lack a strong visual hierarchy, don’t clearly indicate what their core product is, or use generic copy that could apply to almost anything.
Some homepages that get it right: Basecamp
,
Posterous 
Some homepages that don’t: Tweetdeck
,
Gravity Bear
The most important sentence in an article is the first one. If it doesn’t induce the reader to proceed to the second sentence your article is dead. And if the second sentence doesn’t induce him to continue to the third sentence, it’s equally dead. Of such a progression of sentences, each tugging the reader forward until he is hooked, a writer constructs that fateful unit, the “lead.”